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MT-RNR2

Human gene

MT-RNR2

Mitochondrially encoded 16S RNA is the mitochondrial large subunit ribosomal RNA that in humans is encoded by the MT-RNR2 gene. The MT-RNR2 gene also encodes the Humanin polypeptide that has been the target of Alzheimer's disease research.

MT-RNR2
mitochondrially encoded 16S RNA
Identifiers
SymbolMT-RNR2
Alt. symbolsMTRNR2
NCBI gene4550
HGNC7471
UniProtQ8IVG9
Other data
LocusChr. MT
Search for
StructuresSwiss-model
DomainsInterPro
Location of the MT-RNR2 gene on the H strand of the human mitochondrial genome. MT-RNR2, or RRNL, is one of the two mitochondrial ribosomal RNA genes (blue boxes).

Mitochondrially encoded 16S RNA (often abbreviated as 16S) is the mitochondrial large subunit ribosomal RNA[1][2] that in humans is encoded by the MT-RNR2 gene. The MT-RNR2 gene also encodes the Humanin polypeptide that has been the target of Alzheimer's disease research.[3]

The 16S rRNA is the mitochondrial homologue of the prokaryotic 23S and eukaryotic nuclear 28S ribosomal RNAs.[4]

See also

References

  1. ↑ Noda R, Kim CG, Takenaka O, Ferrell RE, Tanoue T, Hayasaka I, et al. (2001). "Mitochondrial 16S rRNA sequence diversity of hominoids". The Journal of Heredity. 92 (6): 490–496. doi:10.1093/jhered/92.6.490. PMID 11948216.
  2. ↑ Nagy A, Wilhelm M, Kovacs G (February 2003). "Mutations of mtDNA in renal cell tumours arising in end-stage renal disease". The Journal of Pathology. 199 (2): 237–242. doi:10.1002/path.1273. PMID 12533837. S2CID 35602546.
  3. ↑ Tajima H, Niikura T, Hashimoto Y, Ito Y, Kita Y, Terashita K, et al. (May 2002). "Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults". Neuroscience Letters. 324 (3): 227–231. doi:10.1016/S0304-3940(02)00199-4. PMID 12009529. S2CID 12088367.
  4. ↑ Eperon IC, Anderson S, Nierlich DP (July 1980). "Distinctive sequence of human mitochondrial ribosomal RNA genes". Nature. 286 (5772): 460–467. Bibcode:1980Natur.286..460E. doi:10.1038/286460a0. PMID 6157106. S2CID 4262269.